ABSTRACT
@#Objective: To explore the rats bone biomechanics improvement action after exercise combined with traditional Chinese medicine compound of castration. Method: A total of 100 SPF SD female rats, aged 180 days, were randomly divided into blank group，model group，exercise，traditional Chinese medicine compound，sports combined with traditional Chinese medicine compound group, 20 in each group. Followed conventional breeding 14 days after surgery. 2ml 0.9% sodium chloride was filled to stomach daily for model group and exercise group. 2ml traditional Chinese medicine compound solution was filled to the stomach daily for the traditional Chinese medicine compound and sports combined with traditional Chinese medicine compound group. Besides, the rats were forced to running on flat treadmill 20 minutes daily at speed of 5m/min for exercise group and sports combined with traditional Chinese medicine compound group. After 12 weeks treatment, bilateral femur were collected, attached muscle and connective tissue were took out. Then three-point bending test, microstructure observation, and static parameters of bone trabecula test were completed. Result: BMD, maximal load of femur, and static parameters of bone trabecula test for model group, blank group, exercise group, Chinese medicine compound group, exercise combined with traditional Chinese medicine compound group all have obvious difference from the model group (P<0.01 or P<0.05). Conclusion: Exercise combined with traditional Chinese medicine compound is beneficial for treatment of osteoporosis in castrated rats.